Synthesis and evaluation of the biological activities of some 3-{5-6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl-1,3,4-oxadiazol-2-yl-imino}-1,3-dihydro-2H-indol-2-one derivativesReport as inadecuate




Synthesis and evaluation of the biological activities of some 3-{5-6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl-1,3,4-oxadiazol-2-yl-imino}-1,3-dihydro-2H-indol-2-one derivatives - Download this document for free, or read online. Document in PDF available to download.

Acta Pharmaceutica, Vol.58 No.1 March 2008. -

Reaction of ethyl-6-methyl–2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carboxylates 1a-i with hydrazine hydrate yielded 6-methyl-2-oxo-4-aryl-1,2,3,4-tetrahydropyrimidin-5-carbohydrazides 2a-i. These products on reaction with cyanogen bromide gave 5-5-amino-1,3,4-oxadiazol-2-yl-6-methyl-4-aryl-3,4-dihydropyrimidin-21H-one 3a-i. The resultant aminooxadiazolylpyrimidinones were condensed with isatin to obtain various 3-{5-6-methyl-4-aryl-2-oxo-1,2,3,4-tetrahydropyrimidin-5-yl-1,3,4-oxadiazol-2-yl-imino}-1,3-dihydro-2H-indol-2-ones 4a-i. These products were characterized by IR, 1H NMR, mass spectra and elemental analysis. Products 4a-i revealed promising antibacterial, antifungal and antioxidant activity.

pyrimidinyl oxadiazole amines; pyrimidinone oxadiazolyl indolinones; antibacterial; antifungal; antioxidant



Author: SONIA GEORGE - MANOJ KUMAR PARAMESWARAN - ACHARJEE - RAJA CHAKRABORTY - THENGUNGAL KOCHUPAPPY RAVI -

Source: http://hrcak.srce.hr/



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