Microscopic Protonation Mechanism of Branched Polyamines: Polyamidoamine versus Polypropyleneimine Dendrimers*Report as inadecuate




Microscopic Protonation Mechanism of Branched Polyamines: Polyamidoamine versus Polypropyleneimine Dendrimers* - Download this document for free, or read online. Document in PDF available to download.

Croatica Chemica Acta, Vol.80 No.3-4 November 2007. -

The protonation mechanisms of the polyamidoamine PAMAM andpolypropyleneimine PPI

dendrimers are clarified and related to their molecular structure. The overall proton binding

isotherms can be interpreted in terms of a site binding model, which involves a limited number

of parameters, and can be used to gain detailed insight in both macroscopic and microscopic

protonation mechanisms. The protonation of the PAMAM dendrimers is dominated by the

chemical environment of the amine sites, and the sites protonate almost independently leading

to protonation mechanism with a characteristic intermediate core-shell structure. In the case of

PPI, the protonation is dominated by the electrostatic nearest-neighbor repulsions between the

protonated sites, and leads to an intermediate »onion-like« structure where all the odd shells

are protonated.

dendrimer; polyamine; protonation; mechanism; PAMAM; PPI; hyperbranched; polyelectrolyte; gene vector; transfection



Author: Duško Čakara - ; Laboratory of Physical Chemistry, Department of Chemistry, Faculty of Science, University of Zagreb, Zagreb, C

Source: http://hrcak.srce.hr/



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