Effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatmentReport as inadecuate




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To investigate the effect of Flunixin meglumine- a NSAID; alone and in combination with hypertonic saline on endotoxemic buffalo calves, two groups of five apparently healthy male buffalo calves aged be-tween 6-8 months were subjected to I.V. infusion of E.coli endotoxin at the rate of 5μg-kg BW per hour for 3 hours. A highly significant P < 0.01 fall in mean systolic,diastolic, pulse, mean arterial pressure M.A.P, central venous pressure C.V.P and haemo-globin was observed till the end of endotoxin infusion while respiratory rate was significantly elevated along with a non-significant alteration in rectal tem-perature and hematocrit during the infusion of en-dotoxin. Immediately at the end of endotoxin infusion, flunixin meglumine at the rate of 1.1 mg-kg B.W was infused i.v. in group-I animals and group-II animals were infused with hypertonic saline solution H.S.S. at the rate of 4 ml-Kg BW as one time infusion fol-lowed by flunixin meglumine at the rate of 1.1 mg-kg B.W which resulted in increase of various parameters either to normal or very close to normal value while the rectal temperature and haematocrit decreased non-significantly throughout the observation period of 7 hours. No improvement in Hb and respiration was observed consequent to FM administration. Both treatments successfully raised systolic, diastolic, pulse pressure, C.V.P & M.A.P to normal pre-infusion val-ues. From the results of the present investigation, it can be concluded that i.v. infusion of FM alone and in combination with hypertonic saline solution in en-dotoxemic buffalo calves effectively restores the various hemodynamic parameters close to normal pre-infusion values and it can be used as immediate resuscitation measure to provide the clinician valu-able time to plan further long term treatment.

KEYWORDS

Buffalo Calves; Flunixin Meglumine; Haemodynamics; Hypertonic Saline; Endotoxic Shock

Cite this paper

Singh, D. , Bansal, S. and Ghumman, G. 2011 Effect of flunixin meglumine alone and in combination on haemodynamics during bovine endotoxic shock and after treatment. Journal of Biomedical Science and Engineering, 4, 29-33. doi: 10.4236-jbise.2011.41004.





Author: D. V. Singh, S. K. Bansal, G. S. Ghumman

Source: http://www.scirp.org/



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