Kinetic of Transport of Technogenic Ecotoxicants through Model MembranesReport as inadecuate




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The kinetics of ecotoxicant transport through the membrane was studied. The ecotoxicants studied were pecticides widely used in agriculture: lontrel clopyralid, sencor metribuzin, basagran bentazon, roundup glyphosate, kusagard alloxydim sodium, and sethoxydim, as well as lontrel complexes with cobalt and copper. All compounds considered penetrate through the model phosphatidylcholine liposomal membranes. The transfer rate was monitored by fluorescence quenching of ?-ATP inside the liposomes. The mathematical model for the process was proposed, and the mass transfer rates were calculated. The octanol-water partition constants were determined. All the compounds con- sidered were shown to accumulate in the fatty layer. The kinetics of their accumulation was studied, and the rates of accumulation in the nonpolar phase were calculated, which correlate with the complexation constants of the same compounds. Bioaccumulation of the toxicants is caused by the formation of complexes with the fatty phase lipid part of the cellular membranes. The toxicants under study transferred into the nonpolar phase with a considerable rate dur- ing the whole observation time, namely, 18 months.

KEYWORDS

Ecotoxicant Pesticides, Liposomal Membranes, Mass Transfer Constants, Lipophilicity, Bioaccumulation, Octanol-Water Partition Koct-H2O

Cite this paper

E. Saratovskikh and B. Psikha -Kinetic of Transport of Technogenic Ecotoxicants through Model Membranes,- Journal of Environmental Protection, Vol. 1 No. 4, 2010, pp. 410-419. doi: 10.4236-jep.2010.14047.





Author: Elena A. Saratovskikh, Boris L. Psikha

Source: http://www.scirp.org/



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