African Swine Fever Virus: A ReviewReport as inadecuate


African Swine Fever Virus: A Review


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Dpto. de Biotecnología, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria INIA, Ctra. de la Coruña km 7.5, 28040 Madrid, Spain





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Academic Editors: Linda Dixon and Simon Graham

Abstract African swine fever ASF is a highly contagious viral disease of swine which causes high mortality, approaching 100%, in domestic pigs. ASF is caused by a large, double stranded DNA virus, ASF virus ASFV, which replicates predominantly in the cytoplasm of macrophages and is the only member of the Asfarviridae family, genus Asfivirus. The natural hosts of this virus include wild suids and arthropod vectors of the Ornithodoros genus. The infection of ASFV in its reservoir hosts is usually asymptomatic and develops a persistent infection. In contrast, infection of domestic pigs leads to a lethal hemorrhagic fever for which there is no effective vaccine. Identification of ASFV genes involved in virulence and the characterization of mechanisms used by the virus to evade the immune response of the host are recognized as critical steps in the development of a vaccine. Moreover, the interplay of the viral products with host pathways, which are relevant for virus replication, provides the basic information needed for the identification of potential targets for the development of intervention strategies against this disease. View Full-Text

Keywords: African swine fever virus; ASFV; virus entry; endocytosis; endosomal pathway; host cell targets; cellular responses; ER stress; apoptosis; autophagy; A179L African swine fever virus; ASFV; virus entry; endocytosis; endosomal pathway; host cell targets; cellular responses; ER stress; apoptosis; autophagy; A179L





Author: Inmaculada Galindo and Covadonga Alonso *

Source: http://mdpi.com/



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