Zika Virus: Recent Advances towards the Development of Vaccines and TherapeuticsReport as inadecuate




Zika Virus: Recent Advances towards the Development of Vaccines and Therapeutics - Download this document for free, or read online. Document in PDF available to download.

Center for Vaccine Development, University of Maryland School of Medicine, Baltimore, MD 21201, USA





Academic Editor: Eric Freed

Abstract Zika is a rapidly emerging public health threat. Although clinical infection is frequently mild, significant neurological manifestations have been demonstrated in infants born to Zika virus ZIKV infected mothers. Due to the substantial ramifications of intrauterine infection, effective counter-measures are urgently needed. In order to develop effective anti-ZIKV vaccines and therapeutics, improved animal models and a better understanding of immunological correlates of protection against ZIKV are required. This review will summarize what is currently known about ZIKV, the clinical manifestations and epidemiology of Zika as well as, the development of animal models to study ZIKV infection, host immune responses against ZIKV, and the current state of development of vaccines and therapeutics against ZIKV. View Full-Text

Keywords: Zika virus; animal models; immunology; vaccines; congenital Zika syndrome Zika virus; animal models; immunology; vaccines; congenital Zika syndrome





Author: Monica A. McArthur

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents