Impact of Parvovirus B19 Viremia in Liver Transplanted Children on Anemia: A Retrospective StudyReport as inadecuate


Impact of Parvovirus B19 Viremia in Liver Transplanted Children on Anemia: A Retrospective Study


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1

Institute of Medical Microbiology and Hygiene, University of Regensburg, 93053 Regensburg, Germany

2

Department of Surgery and Transplantation, University Hospital of Zurich, 8091 Zürich, Switzerland





*

Author to whom correspondence should be addressed.



Academic Editors: Christiane Dinsart and Jürg Nüesch

Abstract Acute parvovirus B19 B19V infection in immunocompromised patients may lead to severe anemia. However, in adult transplant recipients, B19V reactivations without anemia and low-level viremia are common. The impact of B19V in pediatric transplant patients, with high risk of primary infection, is investigated here. In a six-month period, 159 blood samples of 54 pediatric liver transplant recipients were tested for B19V DNA by quantitative real-time PCR. Viremia was correlated with anemia and immunosuppression and compared with rates in adult transplant recipients. B19V DNA was detected in 5-54 patients. Primary B19V infections were observed in four patients prior to and in one patient after transplantation. Rates of viremia were significantly higher in pediatric recipients than in adults. Prolonged virus shedding after primary infection prior to transplantation accounts for most viremic cases. Anemia was significantly more frequent in samples from viremic patients, but remained mild. In 15% of anemic samples, B19V DNA was detected. Therefore, in anemic pediatric transplant recipients, diagnostics for B19V seem reasonable. View Full-Text

Keywords: parvovirus B19; children; pediatric; transplantation; anemia parvovirus B19; children; pediatric; transplantation; anemia





Author: Michael Würdinger 1,2, Susanne Modrow 1 and Annelie Plentz 1,*

Source: http://mdpi.com/



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