Heparin-Binding Epidermal Growth Factor-like Growth Factor-Diphtheria Toxin Receptor in Normal and Neoplastic HematopoiesisReport as inadecuate




Heparin-Binding Epidermal Growth Factor-like Growth Factor-Diphtheria Toxin Receptor in Normal and Neoplastic Hematopoiesis - Download this document for free, or read online. Document in PDF available to download.

Department of Medicine, Section of Hematology, Cancer Research & Cell Biology Laboratory, University of Verona, Verona, Italy





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Abstract Heparin-binding EGF-like growth factor HB-EGF belongs to the EGF family of growth factors. It is biologically active either as a molecule anchored to the membrane or as a soluble form released by proteolytic cleavage of the extracellular domain. HB-EGF is involved in relevant physiological and pathological processes spanning from proliferation and apoptosis to morphogenesis. We outline here the main activities of HB-EGF in connection with normal or neoplastic differentiative or proliferative events taking place primitively in the hematopoietic microenvironment. View Full-Text

Keywords: HB-EGF; GPCR; EGFR-ErbB-HER; Hematopoiesis; Leukemia; Myeloma HB-EGF; GPCR; EGFR-ErbB-HER; Hematopoiesis; Leukemia; Myeloma





Author: Fabrizio Vinante * and Antonella Rigo

Source: http://mdpi.com/



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