Wireless and Simultaneous Detections of Multiple Bio-Molecules in a Single Sensor Using Love Wave BiosensorReport as inadecuate




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1

Korea Electronics Technology Institute, Seongnam-si, Gyeonggi-do 463-816, Korea

2

Department of Electronics Engineering, Ajou University, Suwon, Gyeonggi-do 443-749, Korea





*

Author to whom correspondence should be addressed.



Abstract A Love wave-based biosensor with a 440 MHz center frequency was developed for the simultaneous detection of two different analytes of Cartilage Oligomeric Matrix Protein COMP and rabbit immunoglobulin G IgG in a single sensor. The developed biosensor consists of one-port surface acoustic wave SAW reflective delay lines on a 41° YX LiNbO3 piezoelectric substrate, a polymethyl methacrylate PMMA waveguide layer, and two different sensitive films. The Love wave biosensor was wirelessly characterized using two antennas and a network analyzer. The binding of the analytes to the sensitive layers induced a large change in the time positions of the original reflection peaks mainly due to the mass loading effect. The assessed time shifts in the reflection peaks were matched well with the predicted values from coupling of mode COM modeling. The sensitivities evaluated from the sensitive films were ~15 deg-µg-mL for the rabbit IgG and ~1.8 deg-ng-mL for COMP. View Full-Text

Keywords: SAW; love wave; biosensor; wireless; batteryfree; IgG; COMP; antenna SAW; love wave; biosensor; wireless; batteryfree; IgG; COMP; antenna





Author: Haekwan Oh 1, Chen Fu 2, Kunnyun Kim 1 and Keekeun Lee 2,*

Source: http://mdpi.com/



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