Intra-Tissue Pressure Measurement in Ex Vivo Liver Undergoing Laser Ablation with Fiber-Optic Fabry-Perot ProbeReport as inadecuate




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1

School of Engineering, Nazarbayev University, 53 Kabanbay Batyr, Astana 01000, Kazakhstan

2

Institute of Image-Guided Surgery IHU, S-c Ircad, STRASBOURG Cedex, Strasbourg 67091, France

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Unit of Measurements and Biomedical Instrumentation, Universita’ Campus Bio-Medico di Roma, via Alvaro del Portillo 21, Roma 00128, Italy

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Optical Fibre Sensors Research Centre OFSRC, University of Limerick, Limerick V94 T9PX, Ireland





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Academic Editor: Manuel Lopez-Amo

Abstract We report the first-ever intra-tissue pressure measurement performed during 1064 nm laser ablation LA of an ex vivo porcine liver. Pressure detection has been performed with a biocompatible, all-glass, temperature-insensitive Extrinsic Fabry-Perot Interferometry EFPI miniature probe; the proposed methodology mimics in-vivo treatment. Four experiments have been performed, positioning the probe at different positions from the laser applicator tip from 0.5 mm to 5 mm. Pressure levels increase during ablation time, and decrease with distance from applicator tip: the recorded peak parenchymal pressure levels range from 1.9 kPa to 71.6 kPa. Different pressure evolutions have been recorded, as pressure rises earlier in proximity of the tip. The present study is the first investigation of parenchymal pressure detection in liver undergoing LA: the successful detection of intra-tissue pressure may be a key asset for improving LA, as pressure levels have been correlated to scattered recurrences of tumors by different studies. View Full-Text

Keywords: fiber optic sensors; pressure measurement; Fabry-Perot; ablation of tissue fiber optic sensors; pressure measurement; Fabry-Perot; ablation of tissue





Author: Daniele Tosi 1, Paola Saccomandi 2,* , Emiliano Schena 3, Dinesh Babu Duraibabu 4, Sven Poeggel 4, Gabriel Leen 4 and Elfed Lewis 4

Source: http://mdpi.com/



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