A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II MetabolismReport as inadecuate


A Disposable Microfluidic Device with a Screen Printed Electrode for Mimicking Phase II Metabolism


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1

Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, UK

2

Department of Engineering, University of Hull, Cottingham Road, Hull HU6 7RX, UK





*

Author to whom correspondence should be addressed.



Academic Editors: Jesus Iniesta Valcarcel and Craig E. Banks

Abstract Human metabolism is investigated using several in vitro methods. However, the current methodologies are often expensive, tedious and complicated. Over the last decade, the combination of electrochemistry EC with mass spectrometry MS has a simpler and a cheaper alternative to mimic the human metabolism. This paper describes the development of a disposable microfluidic device with a screen-printed electrode SPE for monitoring phase II GSH reactions. The proposed chip has the potential to be used as a primary screening tool, thus complementing the current in vitro methods. View Full-Text

Keywords: metabolism; electrochemistry; screen-printed electrodes; mass spectrometry metabolism; electrochemistry; screen-printed electrodes; mass spectrometry





Author: Rafaela Vasiliadou 1,* , Mohammad Mehdi Nasr Esfahani 2, Nathan J. Brown 2 and Kevin J. Welham 1

Source: http://mdpi.com/



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