In Vivo Bioimpedance Spectroscopy Characterization of Healthy, Hemorrhagic and Ischemic Rabbit Brain within 10 Hz–1 MHzReport as inadecuate


In Vivo Bioimpedance Spectroscopy Characterization of Healthy, Hemorrhagic and Ischemic Rabbit Brain within 10 Hz–1 MHz


In Vivo Bioimpedance Spectroscopy Characterization of Healthy, Hemorrhagic and Ischemic Rabbit Brain within 10 Hz–1 MHz - Download this document for free, or read online. Document in PDF available to download.

1

Department of Biomedical Engineering, Fourth Military Medical University, Xi’an 710032, China

2

Department of Neurosurgery, Xijing hospital, Fourth Military Medical University, Xi’an 710032, China





*

Authors to whom correspondence should be addressed.



Academic Editor: Nicole Jaffrezic-Renault

Abstract Acute stroke is a serious cerebrovascular disease and has been the second leading cause of death worldwide. Conventional diagnostic modalities for stroke, such as CT and MRI, may not be available in emergency settings. Hence, it is imperative to develop a portable tool to diagnose stroke in a timely manner. Since there are differences in impedance spectra between normal, hemorrhagic and ischemic brain tissues, multi-frequency electrical impedance tomography MFEIT shows great promise in detecting stroke. Measuring the impedance spectra of healthy, hemorrhagic and ischemic brain in vivo is crucial to the success of MFEIT. To our knowledge, no research has established hemorrhagic and ischemic brain models in the same animal and comprehensively measured the in vivo impedance spectra of healthy, hemorrhagic and ischemic brain within 10 Hz–1 MHz. In this study, the intracerebral hemorrhage and ischemic models were established in rabbits, and then the impedance spectra of healthy, hemorrhagic and ischemic brain were measured in vivo and compared. The results demonstrated that the impedance spectra differed significantly between healthy and stroke-affected brain i.e., hemorrhagic or ischemic brain. Moreover, the rate of change in brain impedance following hemorrhagic and ischemic stroke with regard to frequency was distinct. These findings further validate the feasibility of using MFEIT to detect stroke and differentiate stroke types, and provide data supporting for future research. View Full-Text

Keywords: brain impedance spectra; rabbits; stroke brain impedance spectra; rabbits; stroke





Author: Lin Yang 1, Wenbo Liu 2, Rongqing Chen 1, Ge Zhang 1, Weichen Li 1, Feng Fu 1,* and Xiuzhen Dong 1,*

Source: http://mdpi.com/



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