Comparative Study on Inhibitory Activity of Zerumbone and Zerumbone 2,3-Epoxide on NF-κB Activation and NO ProductionReport as inadecuate




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1

Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, 19 Le Thanh Tong Str., Hanoi, Vietnam

2

Anticancer Research Laboratory, Korea Research Institute of Bioscience and Biotechnology, Yuseong, Daejeon 305-600, Korea





*

Author to whom correspondence should be addressed.



Abstract In the present study the significant role of the α,β-unsaturated carbonyl structure in the anti-inflammatory activity of the natural humulane sesquiterpenoids zerumbone and zerumbone 2,3-epoxide was evidenced from a comparative study of the ability of zerumbone and zerumbone 2,3-epoxide to inhibit NF-κB activation and NO production in LPS lipopolysaccharide- stimulated RAW 264.7 cells. The IC50 of these compounds were 1.97 μM ± 0.18 and 30.11 μM ± 4.10 in the NF-κB activation assay and 3.58 μM ± 0.46 and 34.7 μM ± 3.72 in the nitric oxide production assay, respectively.

Keywords: Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production Zerumbone; Zerumbone-2,3-epoxide; NF-κB; NO production





Author: Phan M. GIANG 1,* , Phan T. SON 1, Hui Z. JIN 2, Jeong H. LEE 2 and Jung J. LEE 2

Source: http://mdpi.com/



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