Combined Effect of Green Tea Extract and Vitamin E on Serum and Heart Tissue Lipids, Lipid Metabolizing Enzymes and Histopathological Alteration in Isoproterenol-Induced Myocardial Infarction in RatsReport as inadecuate




Combined Effect of Green Tea Extract and Vitamin E on Serum and Heart Tissue Lipids, Lipid Metabolizing Enzymes and Histopathological Alteration in Isoproterenol-Induced Myocardial Infarction in Rats - Download this document for free, or read online. Document in PDF available to download.

Pharmacy Department, Faculty of Technology and Engineering, The M.S. University of Baroda, Vadodara- 390 001, Gujarat, India





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Abstract The present study investigated the protective effect of green tea and vitamin E combination on serum and heart tissue lipid profile, lipid metabolizing enzymes and histopathological changes in isoproteranol ISO-induced myocardial infarction in rats. Adult male albino rats, treated with ISO 200mg-kg, s.c. for 2 consecutive days at an interval of 24 hrs. showed a significant increase in the levels of triglycerides TG, total cholesterol TC and free fatty acids FFA, in both serum and cardiac tissue. A rise in the levels of phospholipids PL, low density lipoprotein LDL and very low density lipoprotein-cholesterol VLDL-c was also observed in the serum of isoproterenol-intoxicated rats. Further, a decrease in the level of high density lipoprotein-cholesterol HDL-c in serum and phospholipid levels, in the heart of isoproterenol-intoxicated rats was observed. Further a significant decrease in the activities of cholesterol ester synthetase CES and lecithin: cholesterol acyl transferase LCAT was shown whereas lipoprotein lipase LPL was found to be increased. Administration of alcoholic extract 60% polyphenols of green tea 100 mg-kg-day, p.o. and Vitamin E DL-α-Tocopherol acetate 100 mg-kg-day, p.o. together for 30 consecutive days and challenged with ISO on day 29th and 30th , significantly attenuated these alterations and restored the levels of serum and heart lipids along with lipid metabolizing enzymes. Histopathological observations were also in correlation with the biochemical parameters. These findings indicate the protective effect of green tea and vitamin E in combination during ISO-induced myocardial infarction in rats.

Keywords: Green tea; Lipid profile; Vitamin E; Isoproterenol; Histopathology Green tea; Lipid profile; Vitamin E; Isoproterenol; Histopathology





Author: Aman UPAGANLAWAR * and Ramachandran BALARAMAN

Source: http://mdpi.com/



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