Beyond Range: Innovating Fluorescence MicroscopyReport as inadecuate

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The Medical Research Council Cancer Cell Unit, Hutchison-MRC Research Centre, Hills Road, Cambridge CB2 0XZ, UK

Abstract Time-of-Flight ToF technologies are developed mainly for range estimations in industrial applications or consumer products. Recently, it was realized that ToF sensors could also be used for the detection of fluorescence and of the minute changes in the nanosecond-lived electronic states of fluorescent molecules. This capability can be exploited to report on the biochemical processes occurring within living organisms. ToF technologies, therefore, provide new opportunities in molecular and cell biology, diagnostics, and drug discovery. In this short communication, the convergence of the engineering and biomedical communities onto ToF technologies and its potential impact on basic, applied and translational sciences are discussed. View Full-Text

Keywords: Time-of-Flight ToF; fluorescence lifetime; microscopy Time-of-Flight ToF; fluorescence lifetime; microscopy

Author: Alessandro Esposito



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