Synthesis and Biological Evaluation of New Imine- and Amino-Chitosan DerivativesReport as inadecuate




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Chemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt

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Biochemistry Department, Faculty of Science, Alexandria University, Alexandria 21231, Egypt





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Author to whom correspondence should be addressed.



Academic Editor: Jung Kwon John Oh

Abstract N-substituted chitosan derivatives were synthesized through condensation with a number of selected aryl and heteroaryl aldehydes. The synthesis of the amino-derivatives has been carried out by reductive amination with sodium borohydride as reducing agent. Their structures were characterized by FT-IR, 1HNMR, and XRD. The antimicrobial activity of Chitosan Schiff’s base CSB derivatives were investigated against four types of bacteria and two crop-threatening pathogenic fungi, and the results indicated that the antibacterial and antifungal activities of the investigated derivatives are very promising. Additionally, different concentrations of the triazolo-Schiff’s base derivative 3c were used for cytotoxicity screening against Human Breast Adenocarcinoma Cells MCF-7, Human Colon Carcinoma Cells HCT-116, and Human Hepatocellular Liver Carcinoma Cells HepG-2, and the obtained data revealed that the examined compounds have an excellent cell growth inhibitory effects on the cell lines as compared to standard. View Full-Text

Keywords: chitosan; imine; antimicrobial chitosan; imine; antimicrobial





Author: Huda E. Abdelwahab 1, Seham Y. Hassan 1, Galila A. Yacout 2, Mohamed A. Mostafa 1 and Mohamed M. El Sadek 1,*

Source: http://mdpi.com/



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