Reversible Self-Assembly of Backbone-Thermoresponsive Long Chain Hyperbranched PolyN-Isopropyl AcrylamideReport as inadecuate




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1

The Key Laboratory of Space Applied Physics and Chemistry, Ministry of Education and Shanxi Key Laboratory of Macromolecular Science and Technology, School of Science, Northwestern Polytechnical University, Xi’an 710072, China

2

Xi’an Mordern Chemistry Research Institute, Xi’an 710065, China





*

Author to whom correspondence should be addressed.



Academic Editor: Jianxun Ding

Abstract In this paper, we mainly described the reversible self-assembly of a backbone-thermoresponsive, long-chain, hyperbranched polyN-isopropyl acrylamide LCHBPNIPAM in aqueous solution. Here, we revealed a reversible self-assembly behavior of LCHBPNIPAM aqueous solution derived from temperature. By controlling the temperature of LCHBPNIPAM aqueous solution, we tune the morphology of the LCHBPNIPAM self-assemblies. When the solution temperature increased from the room temperature to the lower critical solution temperature of PNIPAM segments, LCHBPNIPAM self-assembled from multi-compartment vesicles into solid micelles. The morphology of LCHBPNIPAM self-assemblies changed from solid micelles to multi-compartment vesicles again when the temperature decreased back to the room temperature. The size presented, at first, an increase, and then a decrease, tendency in the heating-cooling process. The above thermally-triggered self-assembly behavior of LCHBPNIPAM aqueous solution was investigated by dynamic-static light scattering, transmission electron microscopy, atomic force microscopy, fluorescence spectroscopy, 1H nuclear magnetic resonance in D2O, and attenuated total reflectance Fourier transform infrared spectroscopy. These results indicated that LCHBPNIPAM aqueous solution presents a reversible self-assembly process. The controlled release behaviors of doxorubicin from the vesicles and micelles formed by LCHBPNIPAM further proved the feasibility of these self-assemblies as the stimulus-responsive drug delivery system. View Full-Text

Keywords: hyperbranched polymer; reversible self-assembly; polyN-isopropyl acrylamide; thermo-responsiveness; controlled release of drug hyperbranched polymer; reversible self-assembly; polyN-isopropyl acrylamide; thermo-responsiveness; controlled release of drug





Author: Ting-Ting Liu 1, Wei Tian 1,* , Yan-Li Song 1, Yang Bai 2, Peng-Li Wei 1, Hao Yao 1 and Hong-Xia Yan 1

Source: http://mdpi.com/



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