l-Cystine-Crosslinked Polypeptide Nanogel as a Reduction-Responsive Excipient for Prostate Cancer ChemotherapyReport as inadecuate




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1

Department of Urology, the First Hospital of Jilin University, Changchun 130021, China

2

Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China

3

Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Jinan 250117, China



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Academic Editor: Carsten Werner

Abstract Smart polymer nanogel-assisted drug delivery systems have attracted more and more attention in cancer chemotherapy because of their well-defined morphologies and pleiotropic functions in recent years. In this work, an l-cystine-crosslinked reduction-responsive polypeptide nanogel of methoxy polyethylene glycol-polyl-phenylalanine-co-l-cystine mPEG-PLP-co-LC was employed as a smart excipient for RM-1 prostate cancer PCa chemotherapy. Doxorubicin DOX, as a regular chemotherapy drug, was embedded in the nanogel. The loading nanogel marked as NG-DOX was shown to exhibit glutathione GSH-induced swelling and GSH-accelerated DOX release. Subsequently, NG-DOX showed efficient cellular uptake and proliferation inhibition. Furthermore, NG-DOX presented enhanced antitumor efficacy and security in an RM-1 PCa-grafted mouse model in vivo, indicating its great potential for clinical treatment. View Full-Text

Keywords: chemotherapy; l-cystine; polypeptide nanogel; prostate cancer; reduction-responsiveness; smart drug delivery chemotherapy; l-cystine; polypeptide nanogel; prostate cancer; reduction-responsiveness; smart drug delivery





Author: Liang He 1,2,†, Di Li 2,†, Zhongtang Wang 3,* , Weiguo Xu 2, Jixue Wang 1,2, Hui Guo 1,2, Chunxi Wang 1,* and Jianxun Ding 2,*

Source: http://mdpi.com/



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