Electrospun Polylactide-co-glycolide-co-3S-methyl-morpholine-2,5-dione Nanofibrous Scaffolds for Tissue EngineeringReport as inadecuate




Electrospun Polylactide-co-glycolide-co-3S-methyl-morpholine-2,5-dione Nanofibrous Scaffolds for Tissue Engineering - Download this document for free, or read online. Document in PDF available to download.

1

School of Chemical Engineering and Technology, Collaborative Innovation Center of Chemical Science and Chemical Engineering, Tianjin University, Tianjin 300072, China

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Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Tianjin 300072, China

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Key Laboratory of Systems Bioengineering of Ministry of Education, Tianjin University, Tianjin 300072, China

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Department of Physiology and Pathophysiology, Logistics University of Chinese People’s Armed Police Force, Tianjin 300162, China





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Authors to whom correspondence should be addressed.



Academic Editor: Esmaiel Jabbari

Abstract Biomimetic scaffolds have been investigated in vascular tissue engineering for many years. Excellent biodegradable materials are desired as temporary scaffolds to support cell growth and disappear gradually with the progress of guided tissue regeneration. In the present paper, a series of biodegradable copolymers were synthesized and used to prepared micro-nanofibrous scaffolds for vascular tissue engineering. Polylactide-co-glycolide-co-3S-methyl-morpholine-2,5-dione PLA-co-GA-co-MMD copolymers with different l-lactide LA, glycolide GA, and 3S-methyl-2,5-morpholinedione MMD contents were synthesized using stannous octoate as a catalyst. Moreover, the PLA-co-GA-co-MMD nanofibrous scaffolds were prepared by electrospinning technology. The morphology of scaffolds was analyzed by scanning electron microscopy SEM, and the results showed that the fibers are smooth, regular, and randomly oriented with diameters of 700 ± 100 nm. The weight loss of scaffolds increased significantly with the increasing content of MMD, indicating good biodegradable property of the scaffolds. In addition, the cytocompatibility of electrospun nanofibrous scaffolds was tested by human umbilical vein endothelial cells. It is demonstrated that the cells could attach and proliferate well on PLA-co-GA-co-MMD scaffolds and, consequently, form a cell monolayer fully covering on the scaffold surface. Furthermore, the PLA-co-GA-co-MMD scaffolds benefit to excellent cell infiltration after subcutaneous implantation. These results indicated that the PLA-co-GA-co-MMD nanofibrous scaffolds could be potential candidates for vascular tissue engineering. View Full-Text

Keywords: electrospinning; nanofibrous scaffolds; vascular tissue engineering; copolymers electrospinning; nanofibrous scaffolds; vascular tissue engineering; copolymers





Author: Yakai Feng 1,2,3, Wei Lu 1, Xiangkui Ren 1,2,* , Wen Liu 1, Mengyang Guo 1, Ihsan Ullah 1 and Wencheng Zhang 4,*

Source: http://mdpi.com/



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