Cardiorenal Effects of Kappa Opioid Peptides During OntogenyReport as inadecuate




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Department of Physiology & Pharmacology-Paediatrics, Faculty of Medicine, University of Calgary, 3330 Hospital Drive NW, Calgary, T2N 4N1, Canada





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Abstract This review focuses on the physiological roles for kappa opioid receptors KORs in adult animals and humans, as well as in the developing newborn animal. Our recent findings have provided new information that under physiological conditions in conscious newborn animals, activation of KORs with the selective agonist, U-50488H, results in an aquaresis, as previously observed in adult animals and humans. In addition, we have shown in conscious lambs that KORs modulate systemic and renal haemodynamics as well as the arterial baroreflex control of heart rate, providing a previously unidentified role for KORs. View Full-Text

Keywords: kappa opioid peptides; KORs; newborn; physiology kappa opioid peptides; KORs; newborn; physiology





Author: Francine G. Smith * and Wei Qi

Source: http://mdpi.com/



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