Opioid Actions in Primary-Afferent Fibers—Involvement in Analgesia and AnesthesiaReport as inadecuate




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Department of Physiology, Saga Medical School,5-1-1 Nabeshima, Saga 849-8501, Japan





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Abstract Opioids inhibit glutamatergic excitatory transmission from the periphery by activating G-protein coupled opioid receptors in the central terminals of primary-afferent neurons in the spinal substantia gelatinosa, resulting in antinociception. Opioid receptor activation in the peripheral terminals of primary-afferent neurons inhibits the production of action potentials in response to nociceptive stimuli given to the periphery, leading to antinociception. Opioids also exhibit a local anesthetic effect without opioid receptor activation in peripheral nerve fibers. This review article will focus on analgesia and anesthesia produced by the actions of opioids on primary-afferent fibers. View Full-Text

Keywords: opioids; spinal dorsal horn; excitatory synaptic transmission; primary-afferent fiber; action potential conduction opioids; spinal dorsal horn; excitatory synaptic transmission; primary-afferent fiber; action potential conduction





Author: Eiichi Kumamoto * , Kotaro Mizuta and Tsugumi Fujita

Source: http://mdpi.com/



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