Functional and Structural Overview of G-Protein-Coupled Receptors Comprehensively Obtained from Genome SequencesReport as inadecuate




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1

Computational Biology Research Center CBRC, National Institute of Advanced Industrial Science and Technology AIST, 10th Floor, AIST Waterfront Annex Building, 2-4-7 Aomi, Kotou-ku, Tokyo 135-0064, Japan

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Information and Mathematical Science Lab. Inc., Meikei Building, 1-5-21 Ootsuka, Bunkyou-ku, Tokyo 112-0012, Japan





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Abstract An understanding of the functional mechanisms of G-protein-coupled receptors GPCRs is very important for GPCR-related drug design. We have developed an integrated GPCR database SEVENS http:-sevens.cbrc.jp- that includes 64,090 reliable GPCR genes comprehensively identified from 56 eukaryote genome sequences, and overviewed the sequences and structure spaces of the GPCRs. In vertebrates, the number of receptors for biological amines, peptides, etc. is conserved in most species, whereas the number of chemosensory receptors for odorant, pheromone, etc. significantly differs among species. The latter receptors tend to be single exon type or a few exon type and show a high ratio in the numbers of GPCRs, whereas some families, such as Class B and Class C receptors, have long lengths due to the presence of many exons. Statistical analyses of amino acid residues reveal that most of the conserved residues in Class A GPCRs are found in the cytoplasmic half regions of transmembrane TM helices, while residues characteristic to each subfamily found on the extracellular half regions. The 69 of Protein Data Bank PDB entries of complete or fragmentary structures could be mapped on the TM-loop regions of Class A GPCRs covering 14 subfamilies. View Full-Text

Keywords: GPCR; SEVENS database; genome; gene structure; PDB GPCR; SEVENS database; genome; gene structure; PDB





Author: Makiko Suwa 1,* , Minoru Sugihara 1 and Yukiteru Ono 1,2

Source: http://mdpi.com/



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