Synthesis and Biological Screening of 4-Benzyl-2H-phthalazine DerivativesReport as inadecuate




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Chemistry Department, Faculty of Science, Al-Azhar University, 11884, Nasr City, Cairo, Egypt

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Chemistry Department, Faculty of Science, Jazan University, 2097, Jazan, Saudi Arabia

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Chemistry Department, Faculty of Medicine, Jazan University, 82621, Jazan, Saudi Arabia

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Chemistry Department, Faculty of Science, King Khalid University, 9004, Abha, Saudi Arabia





*

Author to whom correspondence should be addressed.



Abstract Preparation of 4-benzyl-2-substituted phthalazin-1-one derivatives 2-8 is reported. Condensation of 4-benzyl-1-chlorophthalazine 9 with a series of different nucleophiles gave 4-benzylphthalazin-1-ylamino derivatives 10-13 and 16 and 4-amino-2-N-4-benzylphthalazin-1-yl-hydrazino-6-arylpyrimidine-5-carbonitriles 14a,b. Interaction of 9 with ambident anions was also studied. 5-Benzyl-6,6a,12-triazobenzoa-anthracen-7-one 15 is obtained from 9 and anthranilic acid derivatives. Treatment of 16 with EtO3CH-Ac2O under reflux afforded the corresponding ethoxymethylene derivative 17, while aqueous ammonium hydroxide treatment afforded carboxamide derivative 18. The structures of the newly synthesized derivatives were confirmed by their elemental analysis, IR, 1H NMR, 13C NMR and mass spectral studies. Antimicrobial activities of some selected compounds were also studied and some of these were found to exhibit promising effects against Gram-positive and Gram-negative bacteria and fungi. View Full-Text

Keywords: phthalazine derivatives; anthracene derivatives; synthesis; antimicrobial activity phthalazine derivatives; anthracene derivatives; synthesis; antimicrobial activity





Author: Ashraf H.F. Abd El-Wahab 1,2,* , Hany M. Mohamed 1,3, Ahmed M. El-Agrody 4, Mohammed A. El-Nassag 1 and Ahmed H. Bedair 1

Source: http://mdpi.com/



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