Nutrigenetics and Metabolic Disease: Current Status and Implications for Personalised NutritionReport as inadecuate




Nutrigenetics and Metabolic Disease: Current Status and Implications for Personalised Nutrition - Download this document for free, or read online. Document in PDF available to download.

HRB Centre for Diet and Health Research, Department of Epidemiology and Public Health, University College Cork, College Road, Cork, Ireland





Abstract Obesity, particularly central adiposity, is the primary causal factor in the development of insulin resistance, the hallmark of the metabolic syndrome MetS, a common condition characterized by dyslipidaemia and hypertension, which is associated with increased risk of cardiovascular disease CVD and type 2 diabetes T2DM. Interactions between genetic and environmental factors such as diet and lifestyle, particularly over-nutrition and sedentary behavior, promote the progression and pathogenesis of these polygenic diet-related diseases. Their current prevalence is increasing dramatically to epidemic proportions. Nutrition is probably the most important environmental factor that modulates expression of genes involved in metabolic pathways and the variety of phenotypes associated with obesity, the MetS and T2DM. Furthermore, the health effects of nutrients may be modulated by genetic variants. Nutrigenomics and nutrigenetics require an understanding of nutrition, genetics, biochemistry and a range of -omic- technologies to investigate the complex interaction between genetic and environmental factors relevant to metabolic health and disease. These rapidly developing fields of nutritional science hold much promise in improving nutrition for optimal personal and public health. This review presents the current state of the art in nutrigenetic research illustrating the significance of gene-nutrient interactions in the context of metabolic disease. View Full-Text

Keywords: nutrigenetics; metabolic health; dietary fat; obesity; insulin resistance; metabolic syndrome; diabetes; metabotype; gene-nutrient interaction nutrigenetics; metabolic health; dietary fat; obesity; insulin resistance; metabolic syndrome; diabetes; metabotype; gene-nutrient interaction





Author: Catherine M. Phillips

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents