Differential Acute Effects of Selenomethionine and Sodium Selenite on the Severity of ColitisReport as inadecuate




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German Institute of Human Nutrition Potsdam-Rehbruecke DIfE, Arthur-Scheunert-Allee 114-116, 14558 Nuthetal, Germany





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Abstract The European population is only suboptimally supplied with the essential trace element selenium. Such a selenium status is supposed to worsen colitis while colitis-suppressive effects were observed with adequate or supplemented amounts of both organic selenomethionine SeMet and inorganic sodium selenite. In order to better understand the effect of these selenocompounds on colitis development we examined colonic phenotypes of mice fed supplemented diets before the onset of colitis or during the acute phase. Colitis was induced by treating mice with 1% dextran sulfate sodium DSS for seven days. The selenium-enriched diets were either provided directly after weaning long-term or were given to mice with a suboptimal selenium status after DSS withdrawal short-term. While long-term selenium supplementation had no effect on colitis development, short-term selenite supplementation, however, resulted in a more severe colitis. Colonic selenoprotein expression was maximized in all selenium-supplemented groups independent of the selenocompound or intervention time. This indicates that the short-term selenite effect appears to be independent from colonic selenoprotein expression. In conclusion, a selenite supplementation during acute colitis has no health benefits but may even aggravate the course of disease. View Full-Text

Keywords: selenomethionine; selenite; colitis; IBD; DSS; oxidative stress selenomethionine; selenite; colitis; IBD; DSS; oxidative stress





Author: Franziska Hiller, Lisa Oldorff, Karolin Besselt and Anna Patricia Kipp *

Source: http://mdpi.com/



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