Vitamin D and 1,25OH2D Regulation of T cellsReport as inadecuate




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1

Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA

2

Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA





*

Author to whom correspondence should be addressed.



Abstract Vitamin D is a direct and indirect regulator of T cells. The mechanisms by which vitamin D directly regulates T cells are reviewed and new primary data on the effects of 1,25 dihydroxyvitamin D 1,25OH2D on human invariant natural killer iNKT cells is presented. The in vivo effects of vitamin D on murine T cells include inhibition of T cell proliferation, inhibition of IFN-γ, IL-17 and induction of IL-4. Experiments in mice demonstrate that the effectiveness of 1,25OH2D requires NKT cells, IL-10, the IL-10R and IL-4. Comparisons of mouse and human T cells show that 1,25OH2D inhibits IL-17 and IFN-γ, and induces T regulatory cells and IL-4. IL-4 was induced by 1,25OH2D in mouse and human iNKT cells. Activation for 72h was required for optimal expression of the vitamin D receptor VDR in human and mouse T and iNKT cells. In addition, T cells are potential autocrine sources of 1,25OH2D but again only 48–72h after activation. Together the data support the late effects of vitamin D on diseases like inflammatory bowel disease and multiple sclerosis where reducing IL-17 and IFN-γ, while inducing IL-4 and IL-10, would be beneficial. View Full-Text

Keywords: vitamin D; T cells; vitamin D receptor vitamin D; T cells; vitamin D receptor





Author: Margherita T. Cantorna 1,2,* , Lindsay Snyder 1, Yang-Ding Lin 1 and Linlin Yang 1

Source: http://mdpi.com/



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