Ginseng Berry Extract Supplementation Improves Age-Related Decline of Insulin Signaling in MiceReport as inadecuate




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1

College of Pharmacy and Gachon Institute of Pharmaceutical Science, Gachon University, Incheon 406-840, Korea

2

Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Korea

3

Center, Amorepacific Corporation, Gyeonggi-do 446-729, Korea

4

Gachon Medical Research Institute, Gil Hospital, Incheon 405-760, Korea





*

Author to whom correspondence should be addressed.



Abstract The aim of this study was to evaluate the effects of ginseng berry extract on insulin sensitivity and associated molecular mechanisms in aged mice. C57BL-6 mice 15 months old were maintained on a regular diet CON or a regular diet supplemented with 0.05% ginseng berry extract GBD for 24 or 32 weeks. GBD-fed mice showed significantly lower serum insulin levels p = 0.016 and insulin resistance scores HOMA-IR p = 0.012, suggesting that GBD improved insulin sensitivity. Pancreatic islet hypertrophy was also ameliorated in GBD-fed mice p = 0.007. Protein levels of tyrosine phosphorylated insulin receptor substrate IRS-1 p = 0.047, and protein kinase B AKT p = 0.037, were up-regulated in the muscle of insulin-injected GBD-fed mice compared with CON-fed mice. The expressions of forkhead box protein O1 FOXO1 p = 0.036 and peroxisome proliferator-activated receptor gamma PPARγ p = 0.032, which are known as aging- and insulin resistance-related genes, were also increased in the muscle of GBD-fed mice. We conclude that ginseng berry extract consumption might increase activation of IRS-1 and AKT, contributing to the improvement of insulin sensitivity in aged mice. View Full-Text

Keywords: ginseng berry; aging; insulin sensitivity ginseng berry; aging; insulin sensitivity





Author: Eunhui Seo 1,2, Sunmi Kim 3, Sang Jun Lee 3, Byung-Chul Oh 2,4 and Hee-Sook Jun 1,2,4,*

Source: http://mdpi.com/



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