Can Skin Exposure to Sunlight Prevent Liver InflammationReport as inadecuate




Can Skin Exposure to Sunlight Prevent Liver Inflammation - Download this document for free, or read online. Document in PDF available to download.

1

Telethon Kids Institute, University of Western Australia, 100 Roberts Rd, Subiaco, Western Australia 6008, Australia

2

Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK

3

University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, EH16 4TJ, UK





*

Author to whom correspondence should be addressed.



Abstract Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease NAFLD. Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation UVR, the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation. View Full-Text

Keywords: sunlight; vitamin D; nitric oxide; liver; inflammation; non-alcoholic fatty liver disease sunlight; vitamin D; nitric oxide; liver; inflammation; non-alcoholic fatty liver disease





Author: Shelley Gorman 1,* , Lucinda J. Black 1, Martin Feelisch 2, Prue H. Hart 1 and Richard Weller 3

Source: http://mdpi.com/



DOWNLOAD PDF




Related documents