Antioxidant-Rich Extract from Plantaginis Semen Ameliorates Diabetic Retinal Injury in a Streptozotocin-Induced Diabetic Rat ModelReport as inadecuate


Antioxidant-Rich Extract from Plantaginis Semen Ameliorates Diabetic Retinal Injury in a Streptozotocin-Induced Diabetic Rat Model


Antioxidant-Rich Extract from Plantaginis Semen Ameliorates Diabetic Retinal Injury in a Streptozotocin-Induced Diabetic Rat Model - Download this document for free, or read online. Document in PDF available to download.

1

Department of Pharmacy and Master Program, Collage of Pharmacy and Health Care, Tajen University, Pingtung County 90741, Taiwan

2

Department of Urology, Jen-Ai Hospital, Taichung City 41625, Taiwan

3

Center for Basic Medical Science, Collage of Health Science, Central Taiwan University of Science and Technology, Taichung City 40601, Taiwan

4

Department of Biotechnology, Collage of Pharmacy and Health Care, Tajen University, Pingtung County 90741, Taiwan





*

Author to whom correspondence should be addressed.



Abstract Plantaginis semen, the dried ripe seed of Plantago asiatica L. or Plantago depressa Willd. Plantaginaceae, has been traditionally used to treat blurred vision in Asia. The aim of this work was to investigate the effect of plantaginis semen ethanol extract PSEE on the amelioration of diabetic retinopathy DR in streptozotocin STZ-diabetic rats. PSEE has abundant polyphenols with strong antioxidant activity. PSEE 100, 200 or 300 mg-kg was oral administrated to the diabetic rats once daily consecutively for 8 weeks. Oral administration of PSEE resulted in significant reduction of hyperglycemia, the diameter of the retinal vessels, and retinal vascular permeability and leukostasis in diabetic rats. In addition, PSEE administration increased the activities of superoxidase dismutase SOD and catalase CAT, and glutathione peroxidase GSH level in diabetic retinae. PSEE treatment inhibited the expression of vascular endothelial growth factor VEGF and hypoxia-inducible factor-1α HIF-1α and the phosphorylation of Akt without altering the Akt protein expression in diabetic retinae. PSEE not only down-regulated the gene expression of hypoxia-inducible factor-1α TNF-α and interleukin-1β IL-1β, but also reduced ICAM-1 and VCAM-1 expression in diabetic retinae. Moreover, PSEE reduced the nuclear factor-κB NF-κB activation and corrected imbalance between histone deacetylases HDAC and histone acetyltransferases HAT activities in diabetic retinae. In conclusion, phenolic antioxidants extract from plantaginis semen has potential benefits in the prevention and-or progression of DR. View Full-Text

Keywords: plantaginis semen; diabetic retinopathy; STZ-diabetic rats; phenolic antioxidants extract plantaginis semen; diabetic retinopathy; STZ-diabetic rats; phenolic antioxidants extract





Author: Thing-Fong Tzeng 1, Wayne Young Liu 2,3, Shorong-Shii Liou 1, Tang-Yao Hong 4 and I-Min Liu 1,*

Source: http://mdpi.com/



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