Dendrimer-Functionalized Laponite Nanodisks as a Platform for Anticancer Drug DeliveryReport as inadecuate


Dendrimer-Functionalized Laponite Nanodisks as a Platform for Anticancer Drug Delivery


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College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China

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CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal





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Academic Editors: Subramanian Tamil Selvan and Sebastien Lecommandoux

Abstract In this study, we synthesized dendrimer-functionalized laponite LAP nanodisks for loading and delivery of anticancer drug doxorubicin DOX. Firstly, LAP was modified with silane coupling agents and succinic anhydride to render abundant carboxyl groups on the surface of LAP. Then, polyamidoamine PAMAM dendrimer of generation 2 G2 were conjugated to form LM-G2 nanodisks. Anticancer drug DOX was then loaded on the LM-G2 with an impressively high drug loading efficiency of 98.4% and could be released in a pH-sensitive and sustained manner. Moreover, cell viability assay results indicate that LM-G2-DOX complexes could more effectively inhibit the proliferation of KB cells a human epithelial carcinoma cell line than free DOX at the same drug concentration. Flow cytometry analysis and confocal laser scanning microscope demonstrated that LM-G2-DOX could be uptaken by KB cells more effectively than free DOX. Considering the exceptional high drug loading efficiency and the abundant dendrimer amine groups on the surface that can be further modified, the developed LM-G2 nanodisks may hold a great promise to be used as a novel platform for anticancer drug delivery. View Full-Text

Keywords: drug delivery system; laponite; PAMAM dendrimer; anticancer efficacy drug delivery system; laponite; PAMAM dendrimer; anticancer efficacy





Author: Rania Mustafa 1, Yu Luo 1, Yilun Wu 1, Rui Guo 1,* and Xiangyang Shi 1,2,*

Source: http://mdpi.com/



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