T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted SynthesisReport as inadecuate


T1-MRI Fluorescent Iron Oxide Nanoparticles by Microwave Assisted Synthesis


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1

Spanish Cardiovascular Research Centre CNIC and Spanish Pulmonary Diseases Network CIBERES C-Melchor Fernández-Almagro 3, 28029 Madrid, Spain

2

Department of Physicochemistry II, Complutense University of Madrid, 28040 Madrid, Spain





*

Author to whom correspondence should be addressed.



Academic Editor: Yurii Gun'ko

Abstract Iron oxide nanoparticles have long been studied as a T2 contrast agent in MRI due to their superparamagnetic behavior. T1-based positive contrast, being much more favorable for clinical application due to brighter and more accurate signaling is, however, still limited to gadolinium- or manganese-based imaging tools. Though being the only available commercial positive-contrast agents, they lack an efficient argument when it comes to biological toxicity and their circulatory half-life in blood. The need arises to design a biocompatible contrast agent with a scope for easy surface functionalization for long circulation in blood and-or targeted imaging. We hereby propose an extremely fast microwave synthesis for fluorescein-labeled extremely-small iron oxide nanoparticles fdIONP, in a single step, as a viable tool for cell labeling and T1-MRI. We demonstrate the capabilities of such an approach through high-quality magnetic resonance angiographic images of mice. View Full-Text

Keywords: iron oxide nanoparticles; MRI; T1 contrast; microwave iron oxide nanoparticles; MRI; T1 contrast; microwave





Author: Riju Bhavesh 1, Ana V. Lechuga-Vieco 1, Jesús Ruiz-Cabello 1,2 and Fernando Herranz 1,*

Source: http://mdpi.com/



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