Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-21H-one and its Thione AnalogueReport as inadecuate


Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-21H-one and its Thione Analogue


Chemistry of Substituted Quinolinones. Part VI. Synthesis and Nucleophilic Reactions of 4-Chloro-8-methylquinolin-21H-one and its Thione Analogue - Download this document for free, or read online. Document in PDF available to download.

Department of Chemistry, Faculty of Education, Ain Shams University, Roxy, 11711 Cairo, Egypt





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Abstract The synthesis of 4-chloro-8-methylquinolin-21H-one and its thione analogue is described. Some nucleophilic substitution reactions of the 4-chloro group were carried out to get new 4-substituted 2-quinolinones and quinolinethiones, such as 4-sulfanyl, hydrazino, azido and amino derivatives, which are of important synthetic use. The structure of the new compounds was established by their elemental analysis, IR and 1H-NMR spectra. Also the mass fragmentation pattern of some products is discussed. View Full-Text

Keywords: quinolinone; quinolinethione; nucleophilic substitution; thiol-thione tautomerism; mass fragmentation quinolinone; quinolinethione; nucleophilic substitution; thiol-thione tautomerism; mass fragmentation





Author: Mostafa M. Ismail, Mohamed Abass * and Mohamed M. Hassan

Source: http://mdpi.com/



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