Halogeno Aldol Reaction of Ethyl Vinyl Ketone and Aldehydes Mediated by Titanium TetrachlorideReport as inadecuate


Halogeno Aldol Reaction of Ethyl Vinyl Ketone and Aldehydes Mediated by Titanium Tetrachloride


Halogeno Aldol Reaction of Ethyl Vinyl Ketone and Aldehydes Mediated by Titanium Tetrachloride - Download this document for free, or read online. Document in PDF available to download.

Department of Chemistry and Biochemistry, Texas Tech University, Lubbock TX 79409-1061, USA





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Abstract A three-component halogeno aldol reaction has been developed by using titanium tetrachloride as the halogen source as well as the Lewis acid mediator. The dehydration and elimination of hydrogen chloride were inhibited by conducting the reaction at 0 °C in dichloromethane or at room temperature with a shortened reaction time. Seven examples were examined, giving good to high yields 61 - 92% and modest stereoselectivity syn-anti: 2.2-1.0 - 8.4-1.0. View Full-Text

Keywords: halides; aldol reaction; titanium tetrachloride halides; aldol reaction; titanium tetrachloride





Author: Han-Xun Wei, Subramanian Karur and Guigen Li *

Source: http://mdpi.com/



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