Synthesis and Antimicrobial Activity of Some New Benzimidazole DerivativesReport as inadecuate


Synthesis and Antimicrobial Activity of Some New Benzimidazole Derivatives


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Therapeutical Chemistry Department. National Research Centre, Dokki, Cairo, Egypt





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Abstract Reaction of 3-2-methylbenzimidazol-1-ylpropanoic acid hydrazide 1 with CS2-KOH gave oxadiazole 2 which underwent Mannich reaction to give 3. Compound 2 was treated with hydrazine hydrate to give triazole 4 which was treated with both aldehydes and acetic anhydride to give 5 and 6, respectively. Carbohydrazide 1 was reacted with ethyl acetoacetate, acetylacetone and aldehydes to give 7, 8 and 9, respectively. Cyclocondensation of 9 with thioglycolic and thiolactic acids gave 10 and 11, respectively. Some of these compounds showed potential antimicrobial activities. View Full-Text

Keywords: Methylbenzimidazole; oxadiazole; thioglycolic; thiolactic; triazole; pyrazole; antimicrobial Methylbenzimidazole; oxadiazole; thioglycolic; thiolactic; triazole; pyrazole; antimicrobial





Author: Afaf H. El-masry * , H. H. Fahmy and S. H. Ali Abdelwahed

Source: http://mdpi.com/



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