Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their DerivativesReport as inadecuate




Synthesis, Antibacterial, Antifungal and Antiviral Activity Evaluation of Some New bis-Schiff Bases of Isatin and Their Derivatives - Download this document for free, or read online. Document in PDF available to download.

1

Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran

2

Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

3

Laboratoire SESNAB, Faculté de St Jérôme, Case 342, Université Paul Cézanne, Av. Escadrille Normandie Niémen, 13397 Marseille cedex 20, France





*

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Abstract Twelve new bis-Schiff bases of isatin, benzylisatin and 5-fluoroisatin 3a-3l were prepared by condensation of isatin, benzylisatin and 5-fluoroisatin with primary aromatic amines. The chemical structures of the products were confirmed by 1H- and 13CNMR, IR and mass spectral data. The compounds were screened for antiviral activity against a panel of DNA and RNA viruses. Minimum cytotoxic and minimum virusinhibitory concentrations of these compounds were determined. Compounds 3c and 3i were the most cytotoxic in HEL cells. These newly synthesized bis-Schiff bases were also tested for their antibacterial and antifungal activities. They did not display activity against S. cerevisiae ATCC 28383 or C. albicans CIP 1180-79. View Full-Text

Keywords: Isatin; bis-Schiff base; antibacterial; antiviral; antifungal. Isatin; bis-Schiff base; antibacterial; antiviral; antifungal.





Author: Aliasghar Jarrahpour 1,* , Dariush Khalili 1, Erik De Clercq 2, Chanaz Salmi 3 and Jean Michel Brunel 3

Source: http://mdpi.com/



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