Synthetic Approaches to Heterocyclic Ligands for Gd-Based MRI Contrast AgentsReport as inadecuate




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1

Laboratorio de Síntesis Orgánica e Imagen Molecular por Resonancia Magnética, Facultad de Ciencias, UNED, Paseo Senda del Rey 9, E-28040 Madrid, Spain

2

Departamento de Química Inorgánica y Química Técnica, Facultad de Ciencias, UNED, Paseo Senda del Rey 9, E-28040 Madrid, Spain

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Laboratorio de Imagen Espectroscópica por Resonancia Magnética LIERM, Instituto de Investigaciones Biomédicas -Alberto Sols-, CSIC-UAM, C- Arturo Duperier 4, E-28029 Madrid, Spain





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Abstract Magnetic Resonance Imaging MRI methods are currently used in the clinic for the non invasive detection and characterization of a wide variety of pathologies. Increases in the diagnostic efficiency of MRI have been helped by both the design of dedicated MR sequences revealing specific aspects of the pathology and by the development of more sensitive and selective Contrast Agents CAs, capable of more precisely delineating the borderline regions. In the present review we focus on the synthetic strategies used to obtain MRI CAs containing heterocyclic rings. View Full-Text

Keywords: Lanthanide Complexes; Contrast Agents; Heterocyclic Ligands; MR Imaging Lanthanide Complexes; Contrast Agents; Heterocyclic Ligands; MR Imaging





Author: Elena Pérez-Mayoral 1, Jordi Soler-Padrós 1, Viviana Negri 1, Sebastián Cerdán 3 and Paloma Ballesteros 1,*

Source: http://mdpi.com/



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