Synthesis of Novel Benzimidazolyl-substituted Acrylonitriles and Amidino-substituted Benzimidazo1,2-aQuinolinesReport as inadecuate


Synthesis of Novel Benzimidazolyl-substituted Acrylonitriles and Amidino-substituted Benzimidazo1,2-aQuinolines


Synthesis of Novel Benzimidazolyl-substituted Acrylonitriles and Amidino-substituted Benzimidazo1,2-aQuinolines - Download this document for free, or read online. Document in PDF available to download.

Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, Marulićev trg 20, HR-10000 Zagreb, Croatia





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Abstract A series of novel benzimidazole derivatives 3-10 were synthesized. Benzimidazolyl-substituted acrylonitriles 3 and 4 underwent a photochemical dehydrocyclization reaction to give the corresponding mono- and dicyano-substituted benzimidazo1,2-a quinolines 5 and 6. Pinner reaction of these compounds did not give the expected mono- and diamidines, but rather only compounds 7-10, with amido groups at 6-position were isolated. A mechanism for the reaction is proposed. Acyclic compounds 3 and 4, as well as cyclic benzimidazo1,2-aquinolines 5-8, exhibit interesting spectroscopic properties and are potential biologically active compounds. View Full-Text

Keywords: Benzimidazoles; acrylonitriles; amidines; benzimidazo1; 2-aquinolines; Pinner reaction. Benzimidazoles; acrylonitriles; amidines; benzimidazo1; 2-aquinolines; Pinner reaction.





Author: Marijana Hranjec and Grace Karminski-Zamola *

Source: http://mdpi.com/



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