Synthesis and In-vitro Antitumor Activity of 1-3-Indol-1-ylprop-1-yn-1-ylphthalazines and Related CompoundsReport as inadecuate


Synthesis and In-vitro Antitumor Activity of 1-3-Indol-1-ylprop-1-yn-1-ylphthalazines and Related Compounds


Synthesis and In-vitro Antitumor Activity of 1-3-Indol-1-ylprop-1-yn-1-ylphthalazines and Related Compounds - Download this document for free, or read online. Document in PDF available to download.

Department of Drug and Natural Product Synthesis, Faculty of Life Sciences, University of Vienna, Austria





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Abstract A series of novel 3-indol-1-ylprop-1-yn-1-yl-substituted phthalazines and related azines was prepared via a concise pathway by palladium-catalyzed cross-coupling of appropriate halo-azines and N-propargylindoles. Some of the compounds exhibited significant antitumor activity in an in-vitro assay. View Full-Text

Keywords: 1-3-indol-1-ylprop-1-yn-1-ylphthalazines; N-propargylindoles; palladiumcatalyzed cross-coupling; Sonogashira reaction; antitumor activity. 1-3-indol-1-ylprop-1-yn-1-ylphthalazines; N-propargylindoles; palladiumcatalyzed cross-coupling; Sonogashira reaction; antitumor activity.





Author: Norbert Haider * , Tamara Kabicher, Johann Käferböck and Angelika Plenk

Source: http://mdpi.com/



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