A Facile One-Pot Synthesis of α-Bromo-α,β-unsaturated Esters from AlcoholsReport as inadecuate




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Chemistry Department, College of Science, King Saud University, P.O. Box 2455 Riyadh 11451, Saudi Arabia





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Author to whom correspondence should be addressed.



Abstract Treatment ofN-bromosuccinimide NBS with carboethoxymethylene triphenylphosphorane 1 in CH2Cl2 followed by the addition of an alcohol in the presence of manganese dioxide under ultrasonic irradiation constitutes a stereoselective one-pot procedure for the preparation of Z-configured α–bromo-α,β-unsaturated esters in good to excellent yield.

Keywords: one-pot synthesis; bromoylides; oxidation; α–bromo-α,β-unsaturated esters one-pot synthesis; bromoylides; oxidation; α–bromo-α,β-unsaturated esters





Author: Usama Karama * , Zeid Al-Othman, Abdullah Al-Majid and Abdulrahman Almansour

Source: http://mdpi.com/



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