Flow Injection Spectrophotometric Determination of N-Acetyl-L-cysteine as a Complex with PalladiumIIReport as inadecuate




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1

Department of Analytical Chemistry, Faculty of Chemistry and Technology, Teslina 10-V, 21000 Split, Croatia

2

Department of Mediterranean Agriculture and Aquaculture, University of Zadar, Mihovila Pavlinovića bb, 23000 Zadar, Croatia





*

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Abstract We describe a new method using flow-injection analysis with spectro-photometric detection, suitable for the determination of N-acetyl-L-cysteine NAC. The proposed method is appropriate for the determination of NAC in reaction with Pd2+ ions in the concentration range from 1.0 × 10−5 mol L−1 to 6.0 × 10−5 mol L−1. The detection limit NAC was 5.84 × 10−6 mol L−1 and the recorded relative standard deviation of the method is in the range from 1.67 to 4.11%. NAC and Pd2+ form complexes of Pd2+:NAC molar ratios of 1:1 and 1:2, depending on the ratio of their analytical concentrations. The cumulative conditional stability constant for the PdNAC22+ complex is β12 = 2.69 × 109 L2 mol−2. The proposed method was compared with the classic spectrophotometric determination of NAC, using the same reagent, PdCl2, and had shown certain advantages: a shorter analysis time; b the use of smaller volumes of sample and reagents, which make the proposed method cheaper and faster for NAC determination in real samples without sample pretreatment.

Keywords: flow-injection; spectrophotometry; N-Acetyl-L-cysteine; palladium; complexometry flow-injection; spectrophotometry; N-Acetyl-L-cysteine; palladium; complexometry





Author: Josipa Giljanović 1,* , Mia Brkljača 2 and Ante Prkić 1

Source: http://mdpi.com/



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