A Practical Approach to New 5Z 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one DerivativesReport as inadecuate




A Practical Approach to New 5Z 2-Alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one Derivatives - Download this document for free, or read online. Document in PDF available to download.

1

Chemical Engineering & Molecules for Life Sciences Group, Université de Rennes 1, Sciences Chimiques de Rennes SCR, UMR CNRS 6226, Bât. 10A, Campus de Beaulieu, Avenue du Général Leclerc, CS 74205, 35042 Rennes Cedex, France

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Protein Phosphorylation and Human Disease Group, Station Biologique CNRS, Place G. Tessier, BP 74, 29682 Roscoff, France





*

Author to whom correspondence should be addressed.



Abstract A practical protocol for the preparation of 5Z-2-alkylthio-5-arylmethylene-1-methyl-1,5-dihydro-4H-imidazol-4-one derivatives is reported. The new compounds were obtained in good yield and stereoselectivity in two steps, namely a solvent-free Knoevenagel condensation under microwave irradiation, followed by an S-alkylation reaction with various halogenoalkanes.

Keywords: 1,5-dihydro-4H-imidazol-4one; Knoevenagel condensation; microwave irradiation; S-alkylation 1,5-dihydro-4H-imidazol-4one; Knoevenagel condensation; microwave irradiation; S-alkylation





Author: Khadidja Bourahla 1, Ludovic Paquin 1, Olivier Lozach 2, Laurent Meijer 2, François Carreaux 1 and Jean Pierre Bazureau 1,*

Source: http://mdpi.com/



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