Ultrasound Irradiation Promoted Enzymatic Transesterification of R-S-1-Chloro-3-1-naphthyloxy-2-propanolReport as inadecuate




Ultrasound Irradiation Promoted Enzymatic Transesterification of R-S-1-Chloro-3-1-naphthyloxy-2-propanol - Download this document for free, or read online. Document in PDF available to download.

1

Center of General Surgery, the Second Hospital of Jilin University, Changchun 130041, China

2

Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education, College of Life Sciences, Jilin University, Changchun 130023, China





*

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Abstract R-1-Chloro-3-1-naphthyloxy-2-propanol 3, which is the key intermediate of S-propranolol, was successfully prepared via enantioselective transesterification catalyzed by lipase under ultrasound irradiation. Compared with conventional shaking, the enzyme activity and enantioselectivity were dramatically increased under ultrasound exposure. Effects of various reaction conditions on the synthetic activity of enzyme as well as enantioselectivity, including the type of enzyme, ultrasound power, solvent, acyl donor, temperature and substrate molar ratio, were investigated. Pseudomonas sp. lipase PSL showed an excellent catalytic performance under optimum conditions enzyme activity: 78.3 ± 3.2 μmol·g−1·min−1, E value: 98 ± 6.

Keywords: propranolol; 1-chloro-3-1-naphthyloxy-2-propanol; lipase; transesterification; ultrasound propranolol; 1-chloro-3-1-naphthyloxy-2-propanol; lipase; transesterification; ultrasound





Author: Feng Wang 1, Hong Zhang 2, Jiaxin Wang 2, Ge Chen 2, Xuedong Fang 1, Zhi Wang 2,* and Lei Wang 2,*

Source: http://mdpi.com/



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