Antitrypanosomal Alkaloids from the Marine Bacterium Bacillus pumilusReport as inadecuate




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1

Center for Biodiversity and Drug Discovery, Institute for Scientific Research and High Technology Services, City of Knowledge, P.O. Box 0843-01103, Panama

2

Departamento de Química, Centro de Investigación y de Estudios Avanzados del IPN, México D.F. 07360, Mexico

3

Center for Cellular and Molecular Biology of Diseases, Institute for Scientific Research and High Technology Services, City of Knowledge, P.O. Box 0843-01103, Panama

4

Smithsonian Tropical Research Institute, Balboa, Ancon, P.O. Box 0843-03092, Panama





*

Author to whom correspondence should be addressed.



Abstract Fractionation of the ethyl acetate extract of the marine bacterium Bacillus pumilus isolated from the black coral Antipathes sp. led to the isolation of five compounds: cyclo-L-Leu-L-Pro 1, 3-hydroxyacetylindole 2, N-acetyl-b-oxotryptamine 3, cyclo-L-Phe-L-Pro 4, and 3-formylindole 5. The structures of compounds 1−5 were established by spectroscopic analyses, including HRESITOF-MS and NMR 1H, 13C, HSQC, HMBC and COSY. Compounds 2, 3 and 5 caused the inhibition on the growth of Trypanosoma cruzi T. cruzi, with IC50 values of 20.6, 19.4 and 26.9 μM, respectively, with moderate cytotoxicity against Vero cells. Compounds 1−5 were found to be inactive when tested against Plasmodium falciparum and Leishmania donovani, therefore showing selectivity against T. cruzi parasites.

Keywords: indole alkaloids; Trypanosoma cruzi; Bacillus pumilus; Chagas disease indole alkaloids; Trypanosoma cruzi; Bacillus pumilus; Chagas disease





Author: Sergio Martínez-Luis 1, José Félix Gómez 1,2, Carmenza Spadafora 3, Héctor M. Guzmán 4 and Marcelino Gutiérrez 1,*

Source: http://mdpi.com/



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