Synthesis and Anticancer Activity of Di3-thienylmethanol and Di3-thienylmethaneReport as inadecuate




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1

Plasma Bioscience Research Center, Kwangwoon University, Seoul 139-701, Korea

2

Department of Chemistry, Kwangwoon University, Seoul 139-701, Korea





*

Author to whom correspondence should be addressed.



Abstract Di3-thienylmethanol 2 and di3-thienylmethane 3 have been synthesized and screened against the T98G brain cancer cell line. Treatment induced cell death MTT and macro-colony assay, growth inhibition, cytogenetic damage micronuclei formation, were studied as cellular response parameters. Treatment with the compounds enhanced growth inhibition and cell death in a concentration dependent manner in both T98G and HEK normal cell lines. At higher concentrations 20 µg-mL the cytotoxic effects of the compounds were highly significant. The effect on clonogenic capacity and micronuclei formation observed after treatment of cells. Amongst the compounds, compound 2 exhibited potent activity against T98G brain cancer cells. Despite potent in vitro activity, both compounds exhibited less cytotoxicity against normal human HEK cells at all effective concentrations. View Full-Text

Keywords: thienyl derivatives; T98G gliomas; HEK cells thienyl derivatives; T98G gliomas; HEK cells





Author: Nagendra Kumar Kaushik 1, Hong Seon Kim 2, Young June Chae 2, Young Nam Lee 2, Gi-Chung Kwon 1, Eun Ha Choi 1 and In Tae Kim 2,*

Source: http://mdpi.com/



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