The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BORReport as inadecuate




The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR - Download this document for free, or read online. Document in PDF available to download.

College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea





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Abstract Isolation of compounds from the root of Rhodiola sachalinensis RRS yielded tyrosol 1, salidroside 2, multiflorin B 3, kaempferol-3,4′-di-O-β-D-glucopyranoside 4, afzelin 5, kaempferol 6, rhodionin 7, and rhodiosin 8. Quantification of these compounds was performed by high-performance liquid chromatography HPLC. To investigate the antioxidant and anti-inflammatory effects of the compounds, DPPH radical scavenging, NBT superoxide scavenging and nitric oxide production inhibitory activities were examined in LPS-stimulated Raw 264.7 cells. We suggest that the major active components of RRS are herbacetin glycosides, exhibiting antioxidant activity, and kaempferol, exhibiting anti-inflammatory activity.

Keywords: Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC Rhodiola sachalinensis; antioxidants; radical scavengers; Nitric oxide; HPLC





Author: Kang In Choe, Joo Hee Kwon, Kwan Hee Park, Myeong Hwan Oh, Manh Heun Kim, Han Hyuk Kim, Su Hyun Cho, Eun Kyung Chung, Sung Yi Ha and Min Won Lee *

Source: http://mdpi.com/



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