Anti-Inflammatory Activity of Iridoids and Verbascoside Isolated from Castilleja tenuifloraReport as inadecuate




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1

Facultad de Farmacia, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa., Cuernavaca 62209, Morelos, Mexico

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Centro de Investigaciones Biológicas, Universidad Autónoma del Estado de Morelos, Av. Universidad 1001, Col. Chamilpa., Cuernavaca 62209, Morelos, Mexico

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Instituto de Farmacobiología, Universidad de la Cañada, Carretera Teotitlán - San Antonio Nanahuatipán Km 1.7 s-n., Paraje Titlacuatitla, Teotitlán de Flores Magón 68540, Oax., Mexico



Taken in part from the Ph.D. thesis of Danae Carrillo-Ocampo.





*

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Abstract Castilleja tenuiflora Orobanchaceae has been used in Mexican traditional medicine as a treatment for cough, dysentery, anxiety, nausea and vomiting as well as hepatic and gastrointestinal diseases. The ethanolic extract of the aerial parts of Castilleja tenuiflora was separated by silica gel column chromatography. The fractions were evaluated using the induced edema acetate 12-O-tetradecanoylphorbol TPA anti-inflammatory activity model. The most active fraction was subjected to medium-pressure liquid chromatography MPLC with UV detection at 206 and 240 nm. The following iridoids were isolated: geniposidic acid, aucubin, bartioside, 8-epi-loganin, mussaenoside, and the phenylpropanoid verbascoside. The most active iridoid was geniposidic acid, which was more active than the control indomethacin, and the least active iridoid was mussaenoside. 8-epi-Loganin, and mussaenoside have not been previously reported to be anti-inflammatory compounds. The results of these investigations confirm the potential of Mexican plants for the production of bioactive compounds and validate the ethnomedical use of Castilleja tenuiflora-like anti-inflammatory plants. View Full-Text

Keywords: Castilleja tenuiflora; anti-inflammatory activity; iridoids; TPA Castilleja tenuiflora; anti-inflammatory activity; iridoids; TPA





Author: Danae Carrillo-Ocampo 1,†, Sugeyla Bazaldúa-Gómez 1, Jaime R. Bonilla-Barbosa 2, Rola Aburto-Amar 3 and Verónica Rodríguez-López 1,*

Source: http://mdpi.com/



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