Glycosyl-Nucleolipids as New Bioinspired AmphiphilesReport as inadecuate

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INSERM U869, Bordeaux, F-33076, France


Université de Bordeaux, Bordeaux, F-33076, France

These authors contributed equally to this work.


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Abstract Four new Glycosyl-NucleoLipid GNL analogs featuring either a single fluorocarbon or double hydrocarbon chains were synthesized in good yields from azido thymidine as starting material. Physicochemical studies surface tension measurements, differential scanning calorimetry indicate that hydroxybutanamide-based GNLs feature endothermic phase transition temperatures like the previously reported double chain glycerol-based GNLs. The second generation of GNFs featuring a free nucleobase reported here presents a better surface activity lower glim compared to the first generation of GNFs. View Full-Text

Keywords: nucleolipid; nucleoside; glycosyl; fluorocarbon; amphiphiles; surface tension nucleolipid; nucleoside; glycosyl; fluorocarbon; amphiphiles; surface tension

Author: Laurent Latxague 1,2,†, Amit Patwa 1,2,†, Eric Amigues 1,2 and Philippe Barthélémy 1,2,*



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