68Ga-Labeled Cyclic NGR Peptide for MicroPET Imaging of CD13 Receptor ExpressionReport as inadecuate




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1

Department of Nuclear Medicine, Xijing Hospital, The Fourth Military Medical University, Xian 710032, China

2

Department of Nuclear Medicine, General Hospital of Jinan Military Area Command, Jinan 250031, China

3

Department of Nuclear Medicine, Lanzhou General Hospital of Lanzhou Military Area Command, Lanzhou 730050, China

4

Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA



These authors contributed equally to this work.





*

Authors to whom correspondence should be addressed.



Abstract Peptides containing the asparagines-glycine-arginine NGR motif have been identified as specific ligands binding to CD13-aminopeptidase N APN receptor, a tumor neovascular biomarker. In this study, we synthesized a novel NGR-containing peptide NOTA-G3-NGR, and labeled NOTA-G3-NGR with 68Ga t1-2 = 67.7 min. The resulting 68Ga-NOTA-G3-NGR peptide was subject to in vitro and in vivo characterization. The microPET imaging results revealed that the 68Ga-NOTA-G3-NGR peptide exhibits rapid and specific tumor uptake, and high tumor-to-background contrast in a subcutaneous HT-1080 fibrosarcoma mouse model. We concluded that the 68Ga-NOTA-G3-NGR peptide has potential in the diagnosis of CD13-targeted tumor angiogenesis. View Full-Text

Keywords: microPET imaging; NGR peptide; CD13; tumor angiogenesis; 68Ga labeling microPET imaging; NGR peptide; CD13; tumor angiogenesis; 68Ga labeling





Author: Yahui Shao 1,2,†, Wansheng Liang 3,†, Fei Kang 1, Weidong Yang 1, Xiaowei Ma 1, Guiyu Li 1, Shu Zong 1, Kai Chen 4,* and Jing Wang 1,*

Source: http://mdpi.com/



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