The Effect of Some Fluoroquinolone Family Members on Biospeciation of CopperII, NickelII and ZincII Ions in Human PlasmaReport as inadecuate




The Effect of Some Fluoroquinolone Family Members on Biospeciation of CopperII, NickelII and ZincII Ions in Human Plasma - Download this document for free, or read online. Document in PDF available to download.

1

Faculty of Science, Chemistry Department, University of Kragujevac, P.O.BOX 60, 34000 Kragujevac, Serbia

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Faculty of Pharmacy, Analytical Chemistry Department, University of Belgrade, 11221 Belgrade, Serbia





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Author to whom correspondence should be addressed.



Abstract The speciation of Cu2+, Ni2+ and Zn2+ ions in the presence of the fluoroquinolones FQs moxifloxacin, ofloxacin, levofloxacin and ciprofloxacin, in human blood plasma was studied under physiological conditions by computer simulation. The speciation was calculated using an updated model of human blood plasma including over 6,000 species with the aid of the program Hyss2009. The identity and stability of metal-FQ complexes were determined by potentiometric 310 K, 0.15 mol-L NaCl, spectrophotometric, spectrofluorimetric, ESI-MS and 1H-NMR measurements. In the case of Cu2+ ion the concentration of main low molecular weight LMW plasma complex CuCisHis is very slightly influenced by all examined FQs. FQs show much higher influence on main plasma Ni2+ and Zn2+ complexes: NiHis2 and ZnCysCit, respectively. Levofloxacin exhibits the highest influence on the fraction of the main nickel complex, NiHis2, even at a concentration level of 3 × 10−5 mol-L. The same effect is seen on the main zinc complex, ZnCysCit. Calculated plasma mobilizing indexes indicate that ciprofloxacin possesses the highest mobilizing power from plasma proteins, toward copper ion, while levofloxacin is the most influential on nickel and zinc ions. The results obtained indicate that the drugs studied are safe in relation to mobilization of essential metal ions under physiological conditions. The observed effects were explained in terms of competitive equilibrium reactions between the FQs and the main LMW complexes of the metal ions. View Full-Text

Keywords: copper; nickel; zinc; fluoroquinolones; complexes; biospeciation; blood plasma; computer simulation copper; nickel; zinc; fluoroquinolones; complexes; biospeciation; blood plasma; computer simulation





Author: Predrag Djurdjevic 1,* , Ivan Jakovljevic 1, Ljubinka Joksovic 1, Nevena Ivanovic 1 and Milena Jelikic-Stankov 2

Source: http://mdpi.com/



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