PM00104 Zalypsis®: A Marine Derived Alkylating AgentReport as inadecuate




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1

University of Washington School of Medicine, 1959 NE Pacific St, Seattle, WA 98195, USA

2

Fred Hutchinson Cancer Research Center, University of Washington, 825 Eastlake Avenue East, G-3630, Seattle, WA 98109-1023, USA



These authors contributed equally to this work.





*

Author to whom correspondence should be addressed.



Abstract PM00104 Zalypsis® is a synthethic tetrahydroisoquinolone alkaloid, which is structurally similar to many marine organisms. The compound has been proposed as a potential chemotherapeutic agent in the treatment of solid human tumors and hematological malignancies. PM00104 is a DNA binding agent, causing inhibition of the cell cycle and transcription, which can lead to double stranded DNA breaks. After rigorous pre-clinical testing, the drug has been evaluated in a number of phase II clinical trials. This manuscript provides a review of current trials and appraises the efficacy of PM00104 as a future cancer treatment. View Full-Text

Keywords: PM00104; Zalypsis; alkaloid; chemotherapy; cancer therapy PM00104; Zalypsis; alkaloid; chemotherapy; cancer therapy





Author: Bradley J. Petek 1,† and Robin L. Jones 2,†,*

Source: http://mdpi.com/



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